Preheat oven to 350 degrees ℉. Spray a 12-count muffin tin with non-stick spray.
In a large mixing bowl, add the ground beef, cottage cheese, bread crumbs, onion, ketchup, mustard, garlic powder, chili powder, salt, pepper and egg. Using clean hands or 2 forks, mix well until everything is combined.
Scoop a 1/4 cup of meat mixture into each muffin cup, pressing down into the cup. Repeat with all meatloaf mixture. Bake for 15 minutes.
Topping
In the meantime, in a small bowl, whisk the ketchup and brown sugar and together. Carefully, remove the meatloaf cups from the oven. Spoon 2 teaspoons of topping over each meatloaf cup.
Return meatloaf cups to the oven and bake for an additional 10 minutes or until the meat is cooked through. Serve warm with any extra topping sauce. Enjoy!